- Liittynyt
- 28.10.2016
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Täältä voi lukea Modernan ja Pfizerin mRNA koodin eroista:
Detailed Dissection and Critical Evaluation of the Pfizer/BioNTech and Moderna mRNA Vaccines - PMC
The design of Pfizer/BioNTech and Moderna mRNA vaccines involves many different types of optimizations. Proper optimization of vaccine mRNA can reduce dosage required for each injection leading to more efficient immunization programs. The mRNA ...www.ncbi.nlm.nih.gov
Eroja on.
Modernassa on epäoptimaalisia kodoneja, jotka tekevät translaatiosta epätehokkaamman ja siksi mahdollisesti Modernan annoskoko on suurempi:
As I mentioned before, mRNA-1273 also has a problem in codon optimization (e.g., excessive use of CGG that is not an optimal codon). These factors might jointly impact negatively the translation efficiency of mRNA-1273 and contribute to the requirement of a high dosage of Moderna vaccine (100 μg/dose) relative to that of Pfizer/BioNTech vaccine (30 μg/dose). When an mRNA is not translated efficiently, more of it is needed to produce the same amount of the encoded spike protein.
Ok, kiitos infosta, opinhan uutta tässäkin