- Liittynyt
- 02.11.2016
- Viestejä
- 3 222
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Tekstistä lainattua (kun hakee sen koko tekstin vähän mutkan kautta):
Introduction: Infection with the SARS-CoV-2 coronavirus can lead to a wide range of acute and also chronic disease manifestations. The rapidly developed vaccinations are highly effective in preventing severe disease courses and have been proven safe. Both natural infection and, to a much lower extent, the mRNA-based vaccinations can be accompanied by transient autoimmune phenomena or onset of autoimmune diseases.
Objectives: We report here two cases of multiple sclerosis (MS) with clinical and new radiological signs beginning in close temporal relation to spike (S) protein mRNA-based vaccinations.
Aims: To establish that the onset of MS in these two cases is very likely caused by CD4+ T cell clones that cross-recognize SARS-CoV-2 S protein-derived peptides and peptides derived from myelin proteins, which have previously been implicated in MS.
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Conclusions: Detailed studies of both peripheral blood- and CSF-derived CD4+ T cells show that the onset of MS in these two cases is very likely caused by CD4+ T cell clones that cross-recognize SARS-CoV-2 S protein-derived peptides and peptides derived from myelin proteins, which have previously been implicated in MS.

